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The contamination of seafood with algal toxins can cause severe neuronal and gastrointestinal disorders but also allergies in human. Sporadic outbreaks of poisoning by ingestion of shellfish that has accumulated marine biotoxins have become a world-wide problem. The economic consequences caused by the production of marine biotoxins during algal blooms in the coastal regions are enormous. In this project, fast, simple and cost-effective detection methods for marine biotoxins in seafood as well as patient sera will be developed, based on the application of high-affinity capture antibodies and novel artificial receptor mimics against the toxins.